Gilson Connect
There are many different chromatography techniques, but which is right for your experiment? This video will give an overview of the main differences between analytical and preparative chromatography and help guide you to the technique that is best for your lab's purification research.
Sample preparation for any form of analysis can be tedious and time-consuming, and efforts to automate this process have been long and fruitful. Today, many different types of liquid handlers exist that can perform a variety of functions to increase throughput tremendously. In this application note, we demonstrate one example of sample prep by taking a common but complicated screening method for optimizing liquid-liquid chromatography run parameters and automating the process. We also showcase the use of liquid level detection in the precise liquid handling of biphasic solutions
While more than 220 viruses are known to infect humans, clinically approved antiviral drugs are available for only a dozen of these viruses. CPC is an ideal solution for natural compound investigations. Gilson, in collaboration with Brazilian researchers, recently performed preliminary experiments demonstrating the antiviral activity of compounds that were fractionated from a plant crude extract using CPC. Read more about the study here.
Forsythiaside A, a phenylethanoid glycoside, is one of the major active constituents extracted from the air-dried fruits of Forsythia suspensa and has been reported to possess a wide range of pharmacological properties, including anti-inflammatory and antioxidant activities. This application note discusses a simple, fast, and cost-efficient method to prepare pure compounds using a centrifugal partition chromatography (CPC) system.
The rise of biorenewable alternatives and petroleum/fossil-derived chemicals have led to a growing interest in lignin valorization. In this webinar, Gilson's Dr. Manar Alherech demonstrates the feasibility of isolating valuable compounds from an oxidative lignin depolymerization matrix using centrifugal partition chromatography (CPC).
Researchers are rushing to identify, target, and analyze peptide functions for drug development. Here is what you should know about peptide purification.
To ensure the accuracy of your results, you need to opt between using a positive-displacement pipette vs air-displacement pipette. Here’s what you should know.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the death of motor neurons. A hallmark of ALS is low expression of neurofilament light chain (NFL) in motor neurons. A high-throughput phenotypic assay using patient-derived induced pluripotent stem cells (iPSCs) was used to screen over 6,000 compounds. This poster demonstrates how automation of serial dilutions and dosing on PIPETMAX provides a more accurate and less labor-intensive alternative to manual pipetting for rescreening.
In environments requiring higher throughput levels, manual pipetting methods used in sample preparation, transfer, and mixing can sometimes be time-consuming and prone to procedural errors. Consider these automated liquid handling instruments if you need to increase your sampling throughput without compromising accuracy or repeatability.
The type of pipette you use, and your pipetting technique will have a major impact on the accuracy and results of your assays. Almost every laboratory that conducts research will have a pipetting procedure that accurately measures the exact volumes when aspirating and dispensing liquids. However, if the workflow calls for pipetting dense liquids, making sure you’re using the correct pipette can ensure accuracy in your assays.
